healthcare-cdss-patterns

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npx skills add https://github.com/affaan-m/ecc --skill healthcare-cdss-patterns

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Healthcare CDSS Development Patterns

Patterns for building Clinical Decision Support Systems that integrate into EMR workflows. CDSS modules are patient safety critical — zero tolerance for false negatives.

When to Use

Implementing drug interaction checking
Building dose validation engines
Implementing clinical scoring systems (NEWS2, qSOFA, APACHE, GCS)
Designing alert systems for abnormal clinical values
Building medication order entry with safety checks
Integrating lab result interpretation with clinical context

How It Works

The CDSS engine is a pure function library with zero side effects. Input clinical data, output alerts. This makes it fully testable.

Three primary modules:

`checkInteractions(newDrug, currentMeds, allergies)` — Checks a new drug against current medications and known allergies. Returns severity-sorted InteractionAlert[]. Uses DrugInteractionPair data model.
`validateDose(drug, dose, route, weight, age, renalFunction)` — Validates a prescribed dose against weight-based, age-adjusted, and renal-adjusted rules. Returns DoseValidationResult.
`calculateNEWS2(vitals)` — National Early Warning Score 2 from NEWS2Input. Returns NEWS2Result with total score, risk level, and escalation guidance.

EMR UI
  ↓ (user enters data)
CDSS Engine (pure functions, no side effects)
  ├── Drug Interaction Checker
  ├── Dose Validator
  ├── Clinical Scoring (NEWS2, qSOFA, etc.)
  └── Alert Classifier
  ↓ (returns alerts)
EMR UI (displays alerts inline, blocks if critical)

Drug Interaction Checking

typescript

interface DrugInteractionPair {
  drugA: string;           // generic name
  drugB: string;           // generic name
  severity: 'critical' | 'major' | 'minor';
  mechanism: string;
  clinicalEffect: string;
  recommendation: string;
}

function checkInteractions(
  newDrug: string,
  currentMedications: string[],
  allergyList: string[]
): InteractionAlert[] {
  if (!newDrug) return [];
  const alerts: InteractionAlert[] = [];
  for (const current of currentMedications) {
    const interaction = findInteraction(newDrug, current);
    if (interaction) {
      alerts.push({ severity: interaction.severity, pair: [newDrug, current],
        message: interaction.clinicalEffect, recommendation: interaction.recommendation });
    }
  }
  for (const allergy of allergyList) {
    if (isCrossReactive(newDrug, allergy)) {
      alerts.push({ severity: 'critical', pair: [newDrug, allergy],
        message: `Cross-reactivity with documented allergy: ${allergy}`,
        recommendation: 'Do not prescribe without allergy consultation' });
    }
  }
  return alerts.sort((a, b) => severityOrder(a.severity) - severityOrder(b.severity));
}

Interaction pairs must be bidirectional: if Drug A interacts with Drug B, then Drug B interacts with Drug A.

Dose Validation

typescript

interface DoseValidationResult {
  valid: boolean;
  message: string;
  suggestedRange: { min: number; max: number; unit: string } | null;
  factors: string[];
}

function validateDose(
  drug: string,
  dose: number,
  route: 'oral' | 'iv' | 'im' | 'sc' | 'topical',
  patientWeight?: number,
  patientAge?: number,
  renalFunction?: number
): DoseValidationResult {
  const rules = getDoseRules(drug, route);
  if (!rules) return { valid: true, message: 'No validation rules available', suggestedRange: null, factors: [] };
  const factors: string[] = [];

  // SAFETY: if rules require weight but weight missing, BLOCK (not pass)
  if (rules.weightBased) {
    if (!patientWeight || patientWeight <= 0) {
      return { valid: false, message: `Weight required for ${drug} (mg/kg drug)`,
        suggestedRange: null, factors: ['weight_missing'] };
    }
    factors.push('weight');
    const maxDose = rules.maxPerKg * patientWeight;
    if (dose > maxDose) {
      return { valid: false, message: `Dose exceeds max for ${patientWeight}kg`,
        suggestedRange: { min: rules.minPerKg * patientWeight, max: maxDose, unit: rules.unit }, factors };
    }
  }

  // Age-based adjustment (when rules define age brackets and age is provided)
  if (rules.ageAdjusted && patientAge !== undefined) {
    factors.push('age');
    const ageMax = rules.getAgeAdjustedMax(patientAge);
    if (dose > ageMax) {
      return { valid: false, message: `Exceeds age-adjusted max for ${patientAge}yr`,
        suggestedRange: { min: rules.typicalMin, max: ageMax, unit: rules.unit }, factors };
    }
  }

  // Renal adjustment (when rules define eGFR brackets and eGFR is provided)
  if (rules.renalAdjusted && renalFunction !== undefined) {
    factors.push('renal');
    const renalMax = rules.getRenalAdjustedMax(renalFunction);
    if (dose > renalMax) {
      return { valid: false, message: `Exceeds renal-adjusted max for eGFR ${renalFunction}`,
        suggestedRange: { min: rules.typicalMin, max: renalMax, unit: rules.unit }, factors };
    }
  }

  // Absolute max
  if (dose > rules.absoluteMax) {
    return { valid: false, message: `Exceeds absolute max ${rules.absoluteMax}${rules.unit}`,
      suggestedRange: { min: rules.typicalMin, max: rules.absoluteMax, unit: rules.unit },
      factors: [...factors, 'absolute_max'] };
  }
  return { valid: true, message: 'Within range',
    suggestedRange: { min: rules.typicalMin, max: rules.typicalMax, unit: rules.unit }, factors };
}

Clinical Scoring: NEWS2

typescript

interface NEWS2Input {
  respiratoryRate: number; oxygenSaturation: number; supplementalOxygen: boolean;
  temperature: number; systolicBP: number; heartRate: number;
  consciousness: 'alert' | 'voice' | 'pain' | 'unresponsive';
}
interface NEWS2Result {
  total: number;           // 0-20
  risk: 'low' | 'low-medium' | 'medium' | 'high';
  components: Record<string, number>;
  escalation: string;
}

Scoring tables must match the Royal College of Physicians specification exactly.

Alert Severity and UI Behavior

Severity	UI Behavior	Clinician Action Required
Critical	Block action. Non-dismissable modal. Red.	Must document override reason to proceed
Major	Warning banner inline. Orange.	Must acknowledge before proceeding
Minor	Info note inline. Yellow.	Awareness only, no action required

Critical alerts must NEVER be auto-dismissed or implemented as toast notifications. Override reasons must be stored in the audit trail.

Testing CDSS (Zero Tolerance for False Negatives)

typescript

describe('CDSS — Patient Safety', () => {
  INTERACTION_PAIRS.forEach(({ drugA, drugB, severity }) => {
    it(`detects ${drugA} + ${drugB} (${severity})`, () => {
      const alerts = checkInteractions(drugA, [drugB], []);
      expect(alerts.length).toBeGreaterThan(0);
      expect(alerts[0].severity).toBe(severity);
    });
    it(`detects ${drugB} + ${drugA} (reverse)`, () => {
      const alerts = checkInteractions(drugB, [drugA], []);
      expect(alerts.length).toBeGreaterThan(0);
    });
  });
  it('blocks mg/kg drug when weight is missing', () => {
    const result = validateDose('gentamicin', 300, 'iv');
    expect(result.valid).toBe(false);
    expect(result.factors).toContain('weight_missing');
  });
  it('handles malformed drug data gracefully', () => {
    expect(() => checkInteractions('', [], [])).not.toThrow();
  });
});

Pass criteria: 100%. A single missed interaction is a patient safety event.

Anti-Patterns

Making CDSS checks optional or skippable without documented reason
Implementing interaction checks as toast notifications
Using any types for drug or clinical data
Hardcoding interaction pairs instead of using a maintainable data structure
Silently catching errors in CDSS engine (must surface failures loudly)
Skipping weight-based validation when weight is not available (must block, not pass)

Examples

Example 1: Drug Interaction Check

typescript

const alerts = checkInteractions('warfarin', ['aspirin', 'metformin'], ['penicillin']);
// [{ severity: 'critical', pair: ['warfarin', 'aspirin'],
//    message: 'Increased bleeding risk', recommendation: 'Avoid combination' }]

Example 2: Dose Validation

typescript

const ok = validateDose('paracetamol', 1000, 'oral', 70, 45);
// { valid: true, suggestedRange: { min: 500, max: 4000, unit: 'mg' } }

const bad = validateDose('paracetamol', 5000, 'oral', 70, 45);
// { valid: false, message: 'Exceeds absolute max 4000mg' }

const noWeight = validateDose('gentamicin', 300, 'iv');
// { valid: false, factors: ['weight_missing'] }

Example 3: NEWS2 Scoring

typescript

const result = calculateNEWS2({
  respiratoryRate: 24, oxygenSaturation: 93, supplementalOxygen: true,
  temperature: 38.5, systolicBP: 100, heartRate: 110, consciousness: 'voice'
});
// { total: 13, risk: 'high', escalation: 'Urgent clinical review. Consider ICU.' }

使い方

開始前の確認

Healthcare CDSS Development Patterns

When to Use

How It Works

Drug Interaction Checking

Dose Validation

Clinical Scoring: NEWS2

Alert Severity and UI Behavior

Testing CDSS (Zero Tolerance for False Negatives)

Anti-Patterns

Examples

Example 1: Drug Interaction Check

Example 2: Dose Validation

Example 3: NEWS2 Scoring

タスクに関連する項目

関連する Skills

scientific-thinking-literature-review

docker-patterns

agentic-engineering

backend-patterns

healthcare-cdss-patterns

使い方

開始前の確認

Healthcare CDSS Development Patterns

When to Use

How It Works

Drug Interaction Checking

Dose Validation

Clinical Scoring: NEWS2

Alert Severity and UI Behavior

Testing CDSS (Zero Tolerance for False Negatives)

Anti-Patterns

Examples

Example 1: Drug Interaction Check

Example 2: Dose Validation

Example 3: NEWS2 Scoring

タスクに関連する項目

docker-patterns

finishing-a-development-branch

setup-pre-commit

backend-patterns

関連する Skills

scientific-thinking-literature-review

docker-patterns

agentic-engineering

backend-patterns